Pythons big hearts hold clues for human health cbc news. A shot of snake blood makes the heart grow sciencedirect. Leslie leinwand discusses the python project biofrontiers institute. This resource is a cheatsheet for all of the basic programming concepts for python 3, from variables to decision making to looping. Leslie leinwand, a molecular biologist at the university of colorado at boulder, began investigating this adaptation in.
Leslie leinwand biofrontiers institute university of. Getting started with deep learning for computer vision with. Eating your way to a healthy heart if youre a python. Leslie a leinwands research while affiliated with university of colorado and other places. After the hearts chambers fill with blood, the heart muscle contracts to pump the blood throughout the body see inside a human heart, p. The snakes extreme physiology is why molecular biologist leslie leinwand studies them. Leslie leinwands lab at the university of colorado boulder is working to better understand these dramatic changes in python hearts, which are relevant to enlargement of the human heart. A unique model for extending research opportunities to. Mar 25, 2012 the snakes extreme physiology is why molecular biologist leslie leinwand studies them. Jan 14, 2020 fine art created by leslie allen mermaids, fantasy, couples, angels, horses, birds would love to create a custom painting for you. Leslie leinwands research focuses on how cardiac and skeletal muscle adapt to stimuli, particularly the pathways involved in heart enlargement in response to exercise and disease. To begin to explore the molecular mechanisms of this response, we have sequenced and assembled the fasted and postfed burmese python heart transcriptomes with illumina technology using the chicken gallus gallus. Leslie leinwand will speak about redefining snake oil and how burmese pythons might lead to novel therapeutics.
Leslie leinwand university of colorado boulder, co cub. This is the eighth video to my image recognition basics series. Download the latest version of the free flash plugin. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the. Finding answers for enlarged hearts, communication disorders. Because python organs undergo such a dramatic response to feeding, they. Use features like bookmarks, note taking and highlighting while reading python. As the meal is digested, the heart returns to normal. To begin to explore the molecular mechanisms of this response, we have sequenced and assembled the fasted and postfed burmese python heart transcriptomes with illumina. Facebook gives people the power to share and makes the world more open and connected. Leslie leinwand, a molecular biologist at the university of colorado at boulder, began investigating this adaptation in 2005, dubbing her research team the python.
Oct 29, 2011 lance armstrong and michael phelps undoubtedly have huge hearts, says university of colorado biologist leslie leinwand. Python heart holds surprises that could be of use in. Dilated cardiomyopathy myosin mutants have reduced forcegenerating capacity. This blog post is intended for readers who have purchased a copy of my new book, deep learning for computer vision with python. Python hearts reveal mechanisms relevant to human heart. Leslie leinwand is a professor of the biofrontiers institute at the university of colorado, boulder. Python heart holds surprises that could be of use in cardiology. Address biofrontiers institute university of colorado at boulder campus box 596 boulder, colorado 803090596 phone. We also identified a combination of fatty acids in python plasma that promotes physiological heart growth when injected into either pythons or mice. Leinwand1 burmese pythons display a marked increase in heart mass after a large meal. This article about a biologist from the united states is a stub. In addition to assessing the success of the python project based on the quality and reproducibility of data generated by students, we were interested in how the course shaped their careers and education plans.
The postprandial burmese python displays a remarkable level of cardiac adaptation to high levels of circulating triglycerides and an increased metabolic rate without any evidence of cardiac pathology. Her goal is to translate her labs research findings from the fundamental understanding of the myosin motors and how mutations in them cause disease to the investigation of sex differences in cardiac. The infrequently feeding burmese python python molurus experiences significant and rapid postprandial cardiac hypertrophy followed by regression as digestion is completed. Leslie leinwand has won the american heart associations 2017 distinguished. A unique model for extending research opportunities. Python hearts balloon in size as theyre digesting, and now scientists are studying them for clues about human heart health. This repository contains a poster version working in python 3. Using the python language, i discovered it was possible to basically hijack the entire system of cinema 4d and use it like a graphics and rendering library. They can go for months and months without eating anything, and nothing terrible happens to them. A collection of sketches in a small book kai fine art is an art website, shows painting and illustration works all over the world. Leslie a leinwand s research while affiliated with university of colorado and other places. Postprandial cardiac growth in the python is characterized by cellular hypertrophy and.
Participation in the python project promoted retention in science careers. Hell slithers lust simmers kindle edition by carina nolan. Hhmi professor leslie leinwand s animal model of choice has turned out to be a great way to lure upper class students into handson biology. Revised 11122019 curriculum vitae name leslie anne leinwand citizenship u. Leinwand 1, 1 department of molecular, cellular, and developmental biology, university of colorado. For instance, she says, even a big python never needs a midday dinner or even a weekly meal. Undergraduate science education curricula are traditionally composed of didactic instruction with a small number of laboratory courses that provide introductory training in research techniques. Mar 26, 2012 leinwand thought that python cardiac hypertrophyan increase in the size of heart cellsmight help people. An a3 wall poster which includes the basic syntax for programming in python 3.
Download the books, code, datasets, and any extras associated with your purchase. Leslie a leinwands research works university of colorado. The color is given as a single numerical value for single band images, and a tuple for multiband images. We investigated the molecular mechanisms of this physiological heart growth with the goal of applying this knowledge to the mammalian heart. Whole transcriptome analysis of the fasting and fed. Intramural postdocs sponsored by nigms nih intramural. Development of this article was supported by an hhmi professorship awarded to l. Leslie leinwand s research focuses on how cardiac and skeletal muscle adapt to stimuli, particularly the pathways involved in heart enlargement in response to exercise and disease. These snakes can go a full year without food, and, once they do score a meal, their heart and liver nearly double in size. A unique model for extending research opportunities to undergraduate students. References this article about a biologist from the. Image recognition can be used for all sorts of things like facial recognition, identifying what is in pictures, character. Leslie leinwand has won the american heart associations 2017 distinguished scientist award for outstanding contributions to the field of heart health the usage of fats from python hearts on mammals and the cardiovascular differences between females and males are at the core of research by a university of colorado boulder.
Human hearts can also undergo hypertrophy, either for good or for bad. Crocini works in the laboratory of leslie leinwand, phd, a molecular, cellular, and developmental biology distinguished professor at ucb. Getting started with deep learning for computer vision. Since 1965, the head of the charles regatta has welcomed the worlds best crew teams to the charles river for the ultimate twoday rowing competition. Whole transcriptome analysis of the fasting and fed burmese python heart. Leslie leinwand discusses the python project biofrontiers. This is the same thing that happens to the hearts of long distance runners but to a much greater degree in the python. We found that heart growth in pythons is characterized by myocyte hypertrophy in the absence of cell proliferation and by activation of physiological signal transduction pathways.
Biofrontiers scientist, leslie leinwand holds a burmese python in her lab. During the interview she shared the results of a paper she published in science magazine earlier this year showing that huge amounts of fatty acids circulating in. We will keep the download links stable for automated downloads. Lance armstrong and michael phelps undoubtedly have huge hearts, says university of colorado biologist leslie leinwand. The lab previously found that the increase in python cardiac size is triggered by a combination of fatty acids in python serum, crocini said in a news release. The howard hughes medical institute hhmi and others have challenged administrators of undergraduate science programs to provide more opportunities for research experiences national science foundation, 2000. Mixing drawings, painting, aquarelles and rice paper, tifenn chisels her. A unique model for extending research opportunities to undergraduate students article pdf available in cbe life sciences education 4. Fatty acids identified in the burmese python promote. Leslie leinwand at the university of colorado at boulder coated rat heartmuscle cells with the blood plasma of recently fed. Oct 29, 2011 leslie leinwand became intrigued by the python. In mammals, cardiac hypertrophy occurs via an increase in cardiomyocyte size rather than by hyperplasia and can arise from either pathological or physiological stimuli.
Also to add, if you or anyone else is using opencv. Feb 28, 2019 leslie leinwands lab at the university of colorado boulder is working to better understand these dramatic changes in python hearts, which are relevant to enlargement of the human heart. The downloads page you can use to download the files associated with your purchase of deep learning for computer vision with python. Hell slithers lust simmers kindle edition by carina. Leslie leinwand a university of colorado at boulder molecular biologist who studies heart disease in humans called pythons. Research on learning methodologies suggests this model is relatively ineffective, whereas participation in independent research projects promotes enhanced knowledge acquisition and improves retention of.
Leslie leinwand, an nigms and national heart, lung, and blood institute grantee and a professor at the university of colorado at boulder boulder, colorado, discussed her research on python organs and their connection to. Leslie leinwand s lab at the university of colorado boulder is working to better understand these dramatic changes in python hearts, which are relevant to enlargement of the human heart. Download it once and read it on your kindle device, pc, phones or tablets. Python promote beneficial cardiac growth cecilia a. Tifenn python tifenn python captures the moment of fragility and doubt in her characters. To challenge the level of cardioprotection, we designed an experiment to attempt to induce metabolic syndrome in the burmese python.
Join facebook to connect with leslie leinwand and others you may know. Shes a molecular biologist at the university of colorado, and she studies hearts but mostly mammalian hearts. More depth needed for ks5 but still a reasonable starting point. Despite high levels of circulating lipids, the postprandial python heart does not accumulate triglycerides or fatty acids. Hhmi professor leslie leinwands animal model of choice has turned out to be a great way to lure upper class students into handson biology.
Funding for the python project course was provided by the hhmi and amgen. Leslie leinwand discusses the python project on december 9, biofrontiers institute s chief scientific officer leslie leinwand shared some scaly tales of her research with burmese pythons on nprs science friday. Address biofrontiers institute university of colorado at boulder campus box 596 boulder, colorado 803090596. Download an interview with leslie leinwand or hear. It includes examples to illustrate all of the concepts, and is perfect as a printed handout or poster in your classroom for students to use as reference. Oct 28, 2011 burmese pythons display a marked increase in heart mass after a large meal. Finding answers for enlarged hearts, communication. Sep 23, 2017 after you successfully checkout and purchase your copy of deep learning for computer vision with python you will be redirected to a page that looks similar to the one below. The expanding hearts of pythons have intrigued researchers. Finally, we established a model of extreme physiologic cardiac growth and regression in the burmese python where hearts double in size within 48 hours following a meal and then regress to prefeeding size just as quickly. Whole transcriptome analysis of the fasting and fed burmese. Leinwand thought that python cardiac hypertrophyan increase in the size of heart cellsmight help people.
Movielens latest datasets these datasets will change over time, and are not appropriate for reporting research results. We will not archive or make available previously released versions. Eating your way to a healthy heart if youre a python 90. Leslie leinwand page 2 biofrontiers institute university of. But the growth a human heart is capable of is nothing compared with what a. You can listen to the interview here download the mp3 file on the upper. Within two to three days, you can get anywhere between a 30 and 40 percent increase in the mass of the heart. About a year ago i finally found the perfect medium to work in. Her lab employ the postprandial burmese python as an animal model to discover novel pathways of beneficial cardiac adaptation.
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